A few months ago, in June, I went into ESMFold2, and why it might outclass AlphaFold. It looks like it continues to hold up outside of Biohub's hands...
ESMFold2 is not just AlphaFold with extra parameters and a sharper press kit. And it is certainly not a physics engine in disguise. What it is, instead, is a system that has learned enough of protein biology’s statistical grammar to do serious work without being handed the usual evolutionary scaffolding at inference time.
Admittedly, It's a long shot, but things are moving fast and, in the meantime, I have a long list of people to watch who are forced to update their position on almost daily basis.
A few months ago, in June, I went into ESMFold2, and why it might outclass AlphaFold. It looks like it continues to hold up outside of Biohub's hands...
https://ahalflife.substack.com/p/esmfold2-the-bio-ai-game-is-elimination
To quote:
ESMFold2 is not just AlphaFold with extra parameters and a sharper press kit. And it is certainly not a physics engine in disguise. What it is, instead, is a system that has learned enough of protein biology’s statistical grammar to do serious work without being handed the usual evolutionary scaffolding at inference time.
Great find!
Man, you are such a tasty case of AI denialism. I'm going to subscribe and wait for you to go through all the phases of AI grief.
That’s going to be a boring subscription, but you do you.
Admittedly, It's a long shot, but things are moving fast and, in the meantime, I have a long list of people to watch who are forced to update their position on almost daily basis.