Genes, Minds, Machines

It still wasn’t a lab leak

Six years in, all the evidence points in one direction

Sep 15 • Claus Wilke

40

8

Anthropic has not solved the peptide-binder design problem, but maybe bi[o]hub has

The protein design field is getting pushed forward by human experts in protein design, who would have thought

Sep 3 • Claus Wilke

15

5

3

Has Anthropic solved the peptide-binder design problem?

A small step towards curing all of human disease within the next ten years

Sep 1 • Claus Wilke

35

3

1

August 2026

I'm sorry, you're not going to die from an AI-engineered supervirus

God save us from economists who think they can competently talk about biology

Aug 30 • Claus Wilke

152

62

35

Protein language models are overly constrained by covariation

Why good performance on one set of goals can lead to poor performance on another

Aug 12 • Claus Wilke

20

6

2

The error bar cargo cult

You don't need to understand error bars. You just need to draw them.

Aug 2 • Claus Wilke

51

11

8

July 2026

Nene Royal—A generational talent

The kids in Thailand are alright.

Jul 30 • Claus Wilke

13

8

1

If the work is good why does it need a story?

I thought we do science here, not fiction or romance

Jul 21 • Claus Wilke

26

9

9

How useful are zero-shot predictions of mutational effects?

Zero-shot predictions are great, except for when it matters

Jul 13 • Claus Wilke

18

3

1

“Tell a story” is not helpful advice

If people knew how to tell a story they wouldn't need the advice in the first place

Jul 6 • Claus Wilke

32

4

2

March 2026

The Google Scholar preprint bug strikes again

Google is never going to fix this bug, are they?

Mar 31 • Claus Wilke

8

Creating reproducible data analysis pipelines

There was a discussion recently on Bluesky about reproducible data analysis pipelines.

Mar 27 • Claus Wilke

44

5

4