Genes, Minds, Machines

The Google Scholar preprint bug strikes again

Google is never going to fix this bug, are they?

Mar 31 • Claus Wilke

7

Creating reproducible data analysis pipelines

There was a discussion recently on Bluesky about reproducible data analysis pipelines.

Mar 27 • Claus Wilke

34

5

2

Protein language models are bad at mutational effect prediction

Biology is hard. Yes, even for AI.

Mar 19 • Claus Wilke

21

7

2

February 2026

Sociopathic AI agents

AI alignment will likely require creating AIs with genuine empathy

Feb 15 • Claus Wilke

15

3

3

November 2025

Python is not a great language for data science. Part 2: Language features

It may be a good language for data science, but it’s not a great one.

Nov 17, 2025 • Claus Wilke

35

17

6

Python is not a great language for data science. Part 1: The experience

It may be a good language for data science, but it’s not a great one.

Nov 13, 2025 • Claus Wilke

74

41

9

LLMs excel at programming—how can they be so bad at it?

My explanation for the mystery of why LLMs can be both exceptionally good and quite terrible at programming.

Nov 6, 2025 • Claus Wilke

46

15

11

October 2025

1000 subscribers feedback and AMA thread

A few days ago I broke 1000 subscribers here on Substack.

Oct 26, 2025 • Claus Wilke

9

5

1

Random seeds and brown M&Ms

Your first mistake was assuming people actually understand how random numbers work.

Oct 23, 2025 • Claus Wilke

17

2

3

If your random seed is 42 I will come to your office and set your computer on fire🔥

Figuratively. More likely you'll get a stern talking to.

Oct 22, 2025 • Claus Wilke

66

10

10

Most graduate students propose to do too much

No thesis proposal has ever been critizied for lack of ambition

Oct 16, 2025 • Claus Wilke

27

7

3

We still can’t predict much of anything in biology

Biology is hard. Yes, even for AI.

Oct 7, 2025 • Claus Wilke

96

17

21