AI

Anthropic has not solved the peptide-binder design problem, but maybe bi[o]hub has

The protein design field is getting pushed forward by human experts in protein design, who would have thought

Sep 3 • Claus Wilke

Has Anthropic solved the peptide-binder design problem?

A small step towards curing all of human disease within the next ten years

Sep 1 • Claus Wilke

I'm sorry, you're not going to die from an AI-engineered supervirus

God save us from economists who think they can competently talk about biology

Aug 30 • Claus Wilke

Protein language models are overly constrained by covariation

Why good performance on one set of goals can lead to poor performance on another

Aug 12 • Claus Wilke

How useful are zero-shot predictions of mutational effects?

Zero-shot predictions are great, except for when it matters

Jul 13 • Claus Wilke

Protein language models are bad at mutational effect prediction

Biology is hard. Yes, even for AI.

Mar 19 • Claus Wilke

Sociopathic AI agents

AI alignment will likely require creating AIs with genuine empathy

Feb 15 • Claus Wilke

LLMs excel at programming—how can they be so bad at it?

My explanation for the mystery of why LLMs can be both exceptionally good and quite terrible at programming.

Nov 6, 2025 • Claus Wilke

We still can’t predict much of anything in biology

Biology is hard. Yes, even for AI.

Oct 7, 2025 • Claus Wilke

Teaching data visualization in the time of generative AI

If students want to cheat with AI, the least I can do is make them own up to it.

Sep 12, 2025 • Claus Wilke

Are AI papers now written by AI?

Are AI papers now written by AI?

Aug 12, 2025 • Claus Wilke

"I asked the AI" is not research

You can't reliably fact-check or research obscure topics by asking an AI. It may know less about the topic than you do.

Aug 2, 2025 • Claus Wilke

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